[PDF] Lipid Mediators in Inflammation | Semantic Scholar (2025)

The discovery of AA is reviewed and interventions in AA metabolic pathways are effective ways to manage inflammatory‐related diseases in the clinic and potential clinical applications are discussed.

This review describes the lipid mediators of vascular inflammation and resolution, and their biochemical activity, and highlights data from the literature that often show a worsening of atherosclerotic disease in subjects deficient in lipid mediator of inflammation resolution.

This review summarizes the current knowledge on SPM biosynthesis and classifications, endogenous production profiles and their effects in animal models of bacterial, viral and parasitic infections.

This study investigated a series of polyphenol analogues of natural polyphenols that inhibit the 12-LO pathway in human platelets without affecting other normal functions of the cell, and characterized two novel inhibitors of the 12 -LO pathway that could be promising for subsequent in vivo studies.

Increasing the number of studies targeting the 5-LOX pathway would largely expand knowledge on the anti-inflammatory mechanisms of (poly)phenols.

PAF is identified as an inflammation amplifier in chicken macrophages and ECs, which suggests that PAF could play important roles in the endothelium-innate immunity interface in birds during major bacterial infectious diseases such as colibacillosis.

Evidence supports the relationship between chronic inflammation and cancer and a group of bioactive lipids derived from polyunsaturated fatty acids may have a position as novel anti-inflammatory molecules known as the specialized pro-resolving mediators (SPMs) that could improve the anti-tumor immunity.

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Recent developments on the cellular interactions of these novel anti-inflammatory mediators are reviewed, including aspirin also functions in part via production of novel epimers of lipoxins or 15-epi-lipoxins.

The multiple interaction of lipoxygenases generates compounds that can regulate specific cellular responses of importance in inflammation and immunity.

Novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation are demonstrated.

It is reported that inflammatory exudates from mice treated with ω-3 polyunsaturated fatty acid and aspirin (ASA) generate a novel array of bioactive lipid signals, which provides a novel mechanism for the therapeutic benefits ofπ-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases.

Findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MΦs in tissue homeostasis, inflammation resolution, wound healing, and host defense.

It is reported that lipidomic analysis of exudates obtained in the resolution phase from mice treated with ASA and DHA produce a novel family of bioactive 17R-hydroxy-containing di- and tri-hydroxy-docosanoids termed resolvins that enhance proresolution status.

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